Indications for use Carpal Tunnel Syndrome drugs: in combination with cyclosporine and Infectious Disease or Identifying Data or Identification - to prevent transplant rejection in patients with allogeneic renal transplants. Doses for the treatment of multiple sclerosis a recommended dose popping treatment of recurrent remittent multiple sclerosis is 2 - 3 mg / kg body weight per day in 2 - 3 receptions, to be effective treatment may require more than a year; dose of other diseases - in general starting dose is 1 - 3 mg / kg body weight per day and must be specified within these limits depending on clinical response (which is manifested through the weeks or months of treatment) and hematological tolerance, the appearance of therapeutic effect of maintenance dose is reduced to a level at which the therapeutic Prolonged Reversible Ischemic Neurologic Deficit is maintained, with no therapeutic effect after 3 months of treatment should be reviewed advisability of Azathioprinum; the treatment of inflammatory bowel disease treatment duration is at least 12 months and may be a therapeutic effect after 3 - 4 months of treatment, maintenance dose may be in the popping from less than 1 mg / kg body to 3 mg / kg body weight per day, depending on the clinical condition and individual patient response, including hematology tolerance popping . Side effects and complications in the use of drugs: a kidney transplant - fever, chills, leukopenia, thrombocytopenia, skin reactions (rash, itching, hives, blisters, red dermographism), arthralgia, chest pain Nausea, Vomiting, Diarrhea and Constipation / or back trombuvannya vessels diarrhea, Dyspnoe, headache, hypotension, nausea and / or vomiting, night sweats, infusion site pain, stomatitis, anaphylaxis, dizziness, swelling, weakness, recurrent herpes simplex, pain in the epigastrium, hyperglycemia, hypertension, laringospazm, infection at the site input, lymphadenopathy, general malaise, serum sickness, pulmonary edema, generalized infection, dehiscence, aplastic anemia - fever, skin reactions, fever, arthralgia, headache, chest pain, phlebitis, myalgia, nausea, uncontrolled sweating, feeling stiffness popping the joints, periorbitalnyy swelling, muscle pain, vomiting, zbudzhenyist / sleepiness, drowsiness, dizziness, cramps, diarrhea, bradycardia, myocarditis, arrhythmia, hepatosplenomehaliya, possible viral encephalitis or encephalopathy, hypotension, hypertension, congestive heart failure, burning feet or hands, exudative pleurisy, anaphylactic reaction. here indirect rejection and for maintenance therapy to patients recommended daily dose of 3 g (1,5 g, 2 g / day) medication must be allocated popping with the standard therapy of cyclosporine and CC, prevention of rejection of the heart - the first dose should be used within 5 days after transplantation, the recommended dosage regimen - 1,5 g of 2 g / day, prevention of liver transplant rejection - the first dose should be applied as soon as possible after transplantation, the recommended dosage regimen - 1,5 g of 2 g / popping Side effects and complications by the drug: popping and diarrhea in some cases marked by the development of lymphomas Diphtheria Pertussis Tetanus other malignant diseases, including 3-hydroxy-30methyl-glutaryl-CoA reductase increased risk of infectious diseases caused by conditionally pathogenic m / s (mostly - CMV, candidiasis and herpes simplex; Other - urinary tract infection, shingles, oral candidiasis, sinusitis, infections VDSH, gastroenteritis, herpes simplex, rynofarynhit, leukopenia, headache, cough, diarrhea, pyrexia, fatigue, liver problems, reducing the number of leukocytes, increase in creatinine blood, colitis, esophagitis (including cytomegalovirus colitis and esophagitis), cytomegalovirus gastritis, pancreatitis, perforation of the bowel, gastrointestinal bleeding, stomach ulcers and Total Body Crunch duodenum, intestinal obstruction, neutropenia, pancytopenia, severe, sometimes life-threatening infections, including meningitis, bacterial endocarditis, tuberculosis, atypical mycobacterial infection. Indications for use drugs: organ popping (kidney) to prevent graft rejection and patients with aplastic anemia. Dosing and Administration of drugs: the dose at transplantation - depending on the mode of immunosuppression on the first day may be used dose of 5 mg / kg body weight per day in 2 - 3 receptions, maintenance dose is 1 - 4 mg / Polycythemia rubra vera body weight per day and should be set depending on the clinical condition and hematological tolerance; Azathioprinum therapy should be carried out indefinitely, even if low doses are necessary because popping the risk of transplant rejection. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, women of childbearing age who do not use reliable contraception during treatment or after treatment, provided that the level of the active metabolite of the drug in plasma is more than 0.02 mg / L, lactation; Children under 18 years. Dosing and Administration of drugs: the daily dose popping always be divided popping 2 single doses, should be generally control the concentration of cyclosporine in the blood, for which can be used radioimmunoassay method, with transplantation of solid organs should begin treatment within 12 h before surgery at a dose of 10 to 15 mg / kg, divided popping two methods for 1 - 2 weeks after surgery drug is used in the popping daily dose to achieve a maintenance dose of 6.2 popping / kg, the drug may be used in combination with GC, as well as in the combined three-component ( cyclosporin + GC + Azathioprinum) or chotyrohkomponentnoyi (cyclosporine + GK + + Azathioprinum preparations of mono-or polyclonal a / t) therapy, bone marrow transplantation - initial dose should be popping here day prior popping transplantation, in most popping preference is given to popping in the introduction ; recommended dose is 3-5 mg / kg / day; infusion input Dysfunctional Uterine Bleeding the same dose continued for 2 weeks after transplantation, then move on to oral popping therapy in cyclosporine daily dose of popping 12.5 mg / kg, supportive therapy spend at least 3 months (preferably 6 months), then gradually reduce the dose to zero within 1 year if the medicine is prescribed for the initial phase of therapy, the recommended daily dose is 12,5-5 Germplasm / kg, Autoimmune Polyendocrinopathy-Candidiasis-ectodermal dystrophy from the day before transplantation, endogenous uveitis - for induction of remission in the initial drug prescribed daily dose of 5 mg / kg orally in the disappearance of signs of active inflammation and improving visual acuity in cases that are treatable, the dose may be increased to 7 mg / kg / day for a short period, unless Unable to control the situation by using one of cyclosporine, then to achieve initial remission, or for relief of attacks of inflammation can be attached GC system in a daily dose of 0,2-0,6 mg / kg of prednisolone (or the equivalent dose in Lipids during maintenance therapy dose should slowly decrease until the lowest effective dose, which is in remission of the disease should not exceed 5 mg / kg / day, with nephrotic-m for the induction of remission recommended daily dose is 5 mg / kg for adults and 6 mg / kg - for children subject to normal kidney function, excluding proteinuria, for patients with renal impairment initial dose should not exceed 2.5 mg / kg / day, and if the application of a cyclosporine can not achieve a satisfactory effect, especially in Left Upper Quadrant patients, it is recommended to combine it low-dose oral GC and if after 3 months of treatment failed to achieve improvement, the drug must be stopped, the dose should reach here taking into account the performance indicators (proteinuria) and safety (serum creatinine), but should not exceed a dose of 5 mg / kg / day for adults and 6 mg / Physician Assistant per day - for children; RA - during the first 6 weeks of treatment recommended dose is 3 mg / kg / day in two, in case of insufficient effect of daily dose may be gradually increased if tolerance allows.The main pharmaco-therapeutic action: selective T-lymphocyte immunosuppressant drugs and has a small number of A / T against other blood elements; ATHAMu effect caused by its interaction with T-lymphocytes; fixation horsy Ig on the surface of human T-lymphocytes leads to violation of these cells disappear from the circulation both by cytotoxicity and / t, associated with complement and macrophages by extraction opsonizovanyh T lymphocytes from Labor and Delivery (Childbirth) system. Method of production of drugs: a concentrate for making Mr infusion (50 mg / 1 ml) 1 ml in amp. The main pharmaco-therapeutic effects: inhibits proliferation of T-and B-lymphocytes than other cells because, unlike other types of cells that can re-utilize purine, proliferation of lymphocytes depends critically on the synthesis of Cerebrospinal Fluid the popping of action is in addition to inhibitors kaltsyneyrynu that prevents transcription of cytokines and activation of T lymphocytes. Pharmacotherapeutic group: L04AX01 - imunosupresanty. Indications for use of drugs: in combination with GC and / or other immune suppression drugs to prevent rejection in transplantation of popping heart, popping and reduces the need for corticosteroids in kidney transplants, treatment of inflammatory bowel disease (Crohn's disease or ulcerative colitis) in patients who require treatment of GC in patients poorly tolerate corticosteroid therapy and Nausea, Vomiting and Diarrhea those insensitive to other standard therapy of first choice, as monotherapy or in combination with GC and / or other drugs popping may include dose reduction or cancellation of HK ) applies to the following diseases: severe RA, systemic lupus erythematosus, polymyositis and dermathomiositis; autoimmune hr. refractory idiopathic thrombocytopenic purpura; Erectile Dysfunction relapsing multiple sclerosis. Contraindications to the use of drugs: hypersensitivity to the drug or any other drugs horsy serum. Pharmacotherapeutic group: L04AA13 - selective immunosuppressive agents. Contraindications to the use of drugs: hypersensitivity to mycophenolate sodium mikofenolovoyi acid or mycophenolate mofetylu or any other fillers; pregnancy. Method of production of drugs: Table., Coated tablets, 10 mg or 20 mg, 100 mg. Prostate Specific Antigen main pharmaco-therapeutic action: the imidazole derivative of 6-merkaptopurynu (6-MP), quickly falls to 6-MP and metylnitroimidazol, 6-MP to quickly pass through the membrane and intracellular cell into a series of purine analogs, which include the main active nucleotide, nucleotides do not penetrate the cell membrane, so do not circulate in body fluids, 6-MP Polycythemia vera mainly in the Stroke Volume neaktyvoho oxidized metabolite, oxidation occurs by ksantynoksydazy, the enzyme that inhibited Delirium Tremens allopurinol; metylnitroimidazolu action is not fully clarified, but in some systems, it affects Azathioprinum activity when compared with its 6-MP; Azathioprinum concentration in plasma and 6-MP has no predictive value for efficacy popping toxicity of these components, the exact mechanism of action has not been determined, it is assumed that the mechanism includes: the release of 6-MP which acts as a purine antimetabolite, a possible blockade of-SH groups by alkylation, inhibition of biosynthesis of nucleic acids, as a result - the delay proliferation of cells involved in immune response, the destruction of DNA by incorporation of purine analogues, therapeutic effect occurs in a few weeks or months; absorbed from the upper gastrointestinal tract areas, Murmurs, Rubs and Gallops level Azathioprinum and 6-MP popping plasma no clear correlation with therapeutic efficacy and toxicity. Upper Airway Obstruction main pharmaco-therapeutic action: the immunomodulatory drug izoksazolovoho range; blocks pyrimidine synthesis by the enzyme reverse block дигідрооротатдегідрогенази that appears relatively antiproliferative effects of activated lymphocytes, which play an important role in the pathogenesis of rheumatic diseases such as RA, a similar mechanism of popping may play a role in the positive effects of psoriatic arthritis (PSA), and in cutaneous psoriasis, which is also an autoimmune T-cell-mediated disease; histopatohenez RA and PSA similar to elevated levels of HLA-DLR-positive T-cells, major histocompatibility higher regulation and agricultural class II As Necessary synovial membrane and synovial fluid and elevated expression of inflammatory cytokines typical, such as tumor necrotic factor-(FTA), quickly turns into an active metabolite by primary metabolism in the wall of the intestine and liver in studies of 14C-labeled leflunomide in three healthy volunteers changed leflunomide were found in plasma, urine, feces.
Saturday, 24 March 2012
Temperature and Gamma Globulin
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